What are OEDC Tests?
The OECD Test Guidelines encompass a comprehensive set of internationally recognized testing methodologies employed by various stakeholders such as governmental bodies, industries, and independent laboratories to evaluate the safety of chemical substances and preparations, such as pesticides and industrial chemicals.
OECD 105
Water Solubility
The objective of this Test Guideline is to outline the procedures for ascertaining the water solubility of test substances. Water solubility refers to the maximum concentration of a substance that can be dissolved in water at a specific temperature. This guideline pertains specifically to the determination of water solubility for substances that are stable in water and not volatile, and which are essentially pure. Prior to determining water solubility, it is recommended to gather certain preliminary information about the substance, such as its structural formula, dissociation constant, vapour pressure, and hydrolysis in relation to pH.
OECD 111
Water Solubility
This Test Guideline outlines a laboratory-based method for evaluating abiotic hydrolytic transformations of chemicals in aquatic environments, specifically within the pH range typically found in natural habitats (pH 4-9). The guideline employs a tiered approach, with each tier triggered by the outcomes of the preceding one.
The method entails treating sterile aqueous buffer solutions of varying pH values (pH 4, 7, and 9) with either labelled or non-labelled test substances. Only one concentration should be used, which must not surpass 0.01 M or half of the saturation concentration. These solutions are then placed under controlled laboratory conditions, incubated in the dark at consistent temperatures, and analyzed at suitable time intervals for both the test substance and any resultant hydrolysis products. The preliminary test is conducted at 50 ± 0.5°C and pH 4.0, 7.0, and 9.0, for a duration of 5 days. The second tier investigates the hydrolysis of unstable substances, while the third tier identifies hydrolysis products. The higher tier assessments continue until a 90% hydrolysis of the test substance is observed or for 30 days, whichever occurs first.
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